GLP-1 muscle loss: 25–40% of it is lean mass

Analyses suggest 25–40% of the weight lost on GLP-1 drugs is lean mass, not fat.
That is muscle going out with it.

Why muscle loss runs high here

The faster weight comes off, the larger the share that is muscle — and GLP-1 drugs work fast.
On top of that, a suppressed appetite means protein is usually the first thing to fall short.

• •When portions shrink, protein is what gets squeezed out first
• •Less muscle means a lower metabolic rate, which makes post-drug regain worse
• •It explains the pattern of dropping weight while the mirror barely improves

How much protein

• •1.6 g per kg of body weight is the working floor for preserving muscle in a deficit
• •At 70 kg that is 112 g a day
• •Split it across meals, 25–40 g at a time, rather than one large serving
• •With less room in the stomach, density matters more than ever

What to prioritise on a small appetite

Where you used to finish a plate, you now stop halfway.
What sits in that half decides the outcome.

• •Protein first — this is the part you finish even if you leave the rest
• •Vegetables next; the fibre keeps constipation away
• •Carbohydrates last, placed around training where they get used
• •Filling up on soup or drinks means the protein never lands

Lifting is not optional here

Protein alone is not enough. The body needs a signal that the muscle is still needed.

• •Two or three sessions a week is enough to maintain
• •Start with compound lifts — squat, deadlift, bench press
• •Cut sets before you cut load
• •If energy is low, reduce frequency but hold the weight

How to tell it is going wrong

• •A drop of more than 10% in the weight you can lift
• •Track muscle mass and body fat separately rather than total weight
• •Waist down but arms and legs visibly thinner is a warning

“Losing weight and improving your body are two different results.”